| Samurai Showdown |
| Scratch Golf |
| Shaq Fu |
| Shining Force 2: The Sword of Hajya |
| Shinobi |
| Shinobi 2 |
| Simpsons: Bart vs. the Space Mutants |
| Simpsons: Bart vs. the World |
| Simpsons: Bartman Meets Radioactive Man |
| Simpsons: Krusty's Fun House |
| Simpsons: The Itchy & Scratchy Game |
| Slider |
| Solitaire Fun Pak |
| Solitaire Poker |
| Sonic Blast |
| Sonic Chaos |
| Sonic Drift 2 |
| Sonic Labyrinth |
| Sonic Spinball |
| Sonic The Hedgehog |
| Sonic The Hedgehog 2 |
| Sonic Triple Trouble |
| Space Harrier |
| Spider-Man / X-Men: Arcades Revenge |
| Sports Trivia |
| Star Trek Generations: Beyond the Nexus |
| Star Trek: The Next Generation Advanced Holodeck Tutorial |
| Star Wars |
| Stargate |
| Streets of Rage |
| Streets of Rage 2 |
| Strider 2: Strider Returns |
| Super Battletank |
| Super Columns |
| Super Golf |
| Super Monaco GP |
| Super Off Road |
| Super Smash TV |
| Super Space Invaders |
| Surf Ninjas |
| T2: Terminator 2 Judgment Day |
| T2: The Arcade Game |
| Tails Adventure |
| Tale Spin |
| Taz in Escape from Mars |
| Taz-Mania |
| Tempo Jr. |
| Tengen World Cup Soccer |
| Tesserae |
| Tom & Jerry: The Movie |